Manager, Translational Genetics (Therapeutic Area Genetics)

We are seeking a Translational Genetics Software Engineer, who can help develop and maintain applications and libraries to analyze and interpret millions of sequenced and deeply phenotyped human samples. To enable Regeneron to deliver better medicines to patients, we must be able as scientists to efficiently interact with analysis results from massive human genetics studies. You will work in a team that delivers high quality and flexible tools to perform and interpret large scale genomic analysis results. You will work together with the inclusive and multidisciplinary teams and colleagues at the RGC and Regeneron to translate findings into new biological insights.

As a Translational Genetics Software Developer, a typical day may include:

• Architect elegant solutions, design robust, reusable functions and packages that abstract complex genetic analyses into clean, scalable tools. Transform one-off analyses into production-grade R packages used across the team.

• Build at the intersection of discovery and engineering and enable breakthrough findings in cardiometabolic disease. Mine massive sequencing datasets (2M+ samples) to uncover biological insights that drive drug development.

• Solve real computational challenges, optimize algorithms for performance at scale, refactor legacy codebases, and implement modern software engineering practices (version control, CI/CD, containerization) in a scientific context.

• Debug thorny issues, write comprehensive documentation, and provide technical mentorship to users of your tools.

• Work alongside geneticists, clinicians, and bioinformaticians to understand their analytical needs, then translate those into software solutions that help others. Co-develop novel analysis strategies that push the field forward.

• Integrate cutting-edge methods and stay at the forefront of statistical genetics. You’ll use the latest GWAS and post-GWAS methods, integrate diverse data types, and generating testable hypotheses about human disease. Integrate different sources of data to come-up with new inferences.

This role could be for you if you:

• Have a strong quantitative background and care about writing good code

• Know statistical genetics: polygenic scores, LD, GWAS and post-GWAS, and can disentangle an associated locus without needing a primer.

• Like finding patterns across analyses and refactoring code and duplicated logic into well-designed, composable functions rather than going for copy-paste solutions.

• Want to work in a team that furthers human health using access to unrivalled data.

To be considered for this role, you must have:

• Masters or PhD degree in a Bioinformatics or Statistical Genetics, with a heavy computational component, or a degree in Computer Science, Applied Mathematics, Physics, or other quantitative field with a later specialization in genetics.

• 2+ years of hands-on experience with statistical genetics, GWAS and post-GWAS is essential.

• Strong expertise in writing efficient scientific code in R, Python or other languages.

• Ideally, you’ll have developed scientific packages as well as (web) applications

• Experience developing and deploying in a cloud infrastructure (e.g. AWS, GCP, DNAnexus) using CI/CD and software containerization (Docker).

• Familiarity with standard bioinformatics tools (e.g. PLINK2, HTSlib, tabix) and data formats (e.g. VCF, BED, BGEN).

• Experience working with the Linux/UNIX command line and SQL databases.

Please provide links in your application to any code you may have written and that you are proud of: published tools, software packages, personal projects, etc.

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive culture that provides comprehensive benefits, which vary by location. In the U.S., benefits may include health and wellness programs (including medical, dental, vision, life, and disability insurance), fitness centers, 401(k) company match, family support benefits, equity awards, annual bonuses, paid time off, and paid leaves (e.g., military and parental leave) for eligible employees at all levels! For additional information about Regeneron benefits in the US, please visit For other countries’ specific benefits, please speak to your recruiter.
Please be advised that at Regeneron, we believe we are most successful and work best when we are together. For that reason, many of Regeneron’s roles are required to be performed on-site. Please speak with your recruiter and hiring manager for more information about Regeneron’s on-site policy and expectations for your role and your location.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.

For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location.

Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc.

Salary Range (annually)